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  • Lopes-Ferreira M, Grund LZ, Lima C. Thalassophryne nattereri fish venom: from the envenoming to the understanding of the immune system. J Venom Anim Toxins Incl Trop Dis. 2014 Aug 13;20:35. doi:10.1186/1678-9199-20-35. 
  • Ferreira MJ, Lima C, Lopes-Ferreira M. Anti-inflammatory effect of Natterins, the major toxins from the Thalassophryne nattereri fish venom is dependent on TLR4/MyD88/PI3K signaling pathway. Toxicon. 2014 Sep;87:54-67. doi: 10.1016/j.toxicon.2014.05.014. 
  • Lopes-Ferreira, Mônica ; Ramos, Anderson Daniel ; Martins, Itamar Alves ; Lima, Carla ; Conceição, Katia ; Haddad, Vidal. Clinical manifestations and experimental studies on the spine extract of the toadfish Porichthys porosissimus. Toxicon (Oxford), v. 86, p. 28-39, 2014.
  • Arantes-Costa FM, Grund LZ, Martins MA, Lima C. Airborne pollutant ROFA enhances the allergic airway inflammation through direct modulation of dendritic cells in an uptake-dependent mechanism. Int Immunopharmacol. 2014 Jun 25;22(1):9-20. doi: 10.1016/j.intimp.2014.06.020.
  • Lopes-Ferreira M, Gomes EM, Bruni FM, Ferreira MJ, Charvet P, Lima C. First report of Interruption of mast cell degranulation and endothelial cells activation by anti-inflammatory drugs controlling the acute response provoked by Pseudoplatystoma fasciatum fish venom. Toxicon, DOI: 10.1016/j.toxicon.2014.08.007.


  • The Hierarchical Process of Differentiation of Long-Lived Antibody-Secreting Cells Is Dependent on Integrated Signals Derived from Antigen and IL-17A. Grund LZ, Lopes-Ferreira M, Lima C. PLoS One. 2013 Sep 18;8(9):e74566. 
  • TLR2, TLR4 and the MyD88 Signaling Are Crucial For the In Vivo Generation and the Longevity of Long-Lived Antibody-Secreting Cells. Komegae EN, Grund LZ, Lopes-Ferreira M, Lima C. PLoS One. 2013 Aug 5;8(8):e71185. 
  • The longevity of Th2 humoral response induced by proteases natterins requires the participation of long-lasting innate-like B cells and plasma cells in spleen. Komegae EN, Grund LZ, Lopes-Ferreira M, Lima C. PLoS One. 2013 Jun 28;8(6):e67135. 
  • The anti-inflammatory action of Bothrops jararaca snake antithrombin on acute inflammation induced by carrageenan in mice. de Morais-Zani K, Nunes FP, da Silva JB, Ferreira MJ, Grego KF, Lopes-Ferreira M, Tanaka AS, Tanaka-Azevedo AM. Inflamm Res. 2013 Aug;62(8):733-42.
  • Long-term Type 1 diabetes impairs decidualization and extracellular matrix remodeling during early embryonic development in mice. Favaro, R., Salgado, R., Covarrubias, A., Bruni F., Lima C., Fortes, Z., Zorn T. Placenta (Eastbourne), 2013 in press.


  • Role of interplay between IL-4 and IFN-gamma in the in regulating M1 macrophage Polarization Induced by Nattectin. Ishizuka E.K., Ferreira M.J., Grund L.Z., Coutinho E.M.M., Komegae E.N., Cassado A.A., Bortoluci K.R., Lopes-Ferreira M., Lima C.. International Immunopharmacology. 2012.Dec; 14(4): 513-522.
  • IL-5 and IL-17A are critical for the chronic IgE response and differentiation of long-lived antibody-secreting cells in inflamed tissues. Grund L.Z., Komegae E.N., Lopes-Ferreira M., Lima C. Cytokine. 2012 Aug;59(2):335-351.
  • Potamotrygon cf. henlei stingray mucus: Biochemical features of a novel antimicrobial protein. Conceição K, Monteiro-Dos-Santos J, Seibert C.S., Silva P.I.Jr, Marques E.E., Richardson M., Lopes-Ferreira M. Toxicon. 2012 Oct;60(5):821-829.
  • Local inflammatory response induced by scorpionfish Scorpaena plumieri venom in mice. Menezes T.N., Carnielli J.B., Gomes H.L., Pereira F.E., Lemos E.M., Bissoli N.S., Lopes-Ferreira M., Andrich F., Figueiredo S.G. Toxicon. 2012 Jul;60(1):4-11.
  • Specialization of the sting venom and skin mucus of Cathorops spixii reveals functional diversification of the toxins. Ramos A.D., Conceição K., Silva P.I. Jr., Richardson M., Lima C., Lopes-Ferreira M. Toxicon. 2012 May;59(6):651-665.


  • Structural and biological characterization of Nattectin, a new C-type lectin from the venomous fish Thalassophryne nattereri. Lopes-Ferreira, M.; Magalhães, Santana, G.; Fernandes, J.H.; Junqueira de Azevedo I.M.J.; Ho, P.L.; Lima, C.; Valente, R.; Moura-da-Silva, A.M. Biochimie, v. 93, p. 971-980, 2011. 
  • The action of fish peptide Orpotrin analogs on microcirculation. Conceição, K.; Bruni, F.M.; Santos, J.M.; Melo, R.L.; Marques, E.E.; Fernandez, J.H.; Lopes-Ferreira, M. Journal of Peptide Science, v. 17, p. 192-199, 2011. 
  • Nattectin a fish C-type lectin drives Th1 responses in vivo: Licesses macrophages to differentiate into cells exhibiting typical DC function. Saraiva, T.C.; Grund, L.Z.; Komegae, E.N.; Ramos, A.D.; Conceição, K.; Orii, N.M.; Lopes-Ferreira, M.; Lima, C. International Immunopharmacology, v. 11, p. 1546-1556, 2011. 
  • Studies on pharmacological properties of mucus and sting venom of Potamotrygon cf. henlei. Monteiro-dos-Santos, J.; Conceição, K.; Saibert, C.S.; Marques, E.E.; Ismael, P.; Soares, A.B.; Lima, C.; Lopes-Ferreira, M. International Immunopharmacology, v. 11, p. 1368-1377, 2011. 
  • Insights into the local pathogenesis induced by fish toxins: role of natterins and nattectin in the disruption of cell-cell and cell-extracellular matrix interactions and modulation of cell migration. Komegae, E.N.; Ramos, A.D.; Oliveira, A.K.; Serrano S.M.; Lopes-Ferreira, M.; Lima, C. Toxicon, v. 58, p. 509-517, 2011.  
  • Inflammatory effects of the toxic cyanobacterium Geitlerinema amphibium. Dogo, C.R.; BruniI, F.M.; Elias, F.; Rangel, M.; Pantoja, P.A.; Santanna, C.L.; Lima, C.; Lopes-Ferreira, M.; Carvalho, L.R. Toxicon, v. 58, p. 464-470, 2011. 
  • Disintegrin-like/cysteine-rich domains of the reprolysin HF3: Site-directed mutagenesis reveals essential role of specific residues. Menezes, M.C.; Oliveira, A.K.; Melo, R.L.; Lopes-Ferreira, M.; Rioli, V.; Balan, A.; Paes Leme, A.; Serrano, S.M. Biochimie, v. 93, p. 345-351, 2011. 
  • Bj-PRO-5a, a natural angiotensin-converting enzyme inhibitor, promotes vasodilatation mediated by both bradykinin B2 and M1 muscarinic acetylcholine receptors. Morais, K.L.P.; Hayashi, M.; Bruni, F.M.; Lopes-Ferreira, M.; Camargo, A.C.M.; Ulrich, A.; Lameu, C. Biochemical Pharmacology, v. 81, p. 736-742, 2011. 
  • Carrying progeny on the back: reproduction in the brazilian aquatic frog Pipa carvalhoi. Fernandes, TL.; Antoniazzi, M.M.; Sasso-Cerri, E.; Egami, M.I.; Lima, C; Rodrigues, M.T. ; Jared, C. . South American Journal of Herpetology (Impresso), v. 6, p. 161-176, 2011.


  • Mycobacterium bovis BCG killed by extended freeze-drying targeted plasmacytoid dendritic cells to regulate lung inflammation.Lagranderie, M, Abolhassani, M, Vanoirbeek, J, Lima, C, Balazuc, AM, Huerre, M, Vargaftig, BB, Marchal, G.The Journal of Immunology (1950), v. 184, p. 1062-1070, 2010. 
  • Interleukin-22 is a negative regulator of the allergic response. Schnyder, B, Lima, C, Schnyder-Candrian, S. Cytokine (Philadelphia), v. 50, p. 220-227, 2010. 
  • Inflammatory mediators generated at the site of inoculation of Loxosceles gaucho spider venom. Barbaro, KC, Lira, MS, Araújo, CA, Pareja-Santos, A, Távora BC, Prezotto-Neto, JP, Kimura LF, Lima, C, Lopes-Ferreira M, Santoro, ML. Toxicon (Oxford), v. 56, p. 972-979, 2010. 
  • Studies on Terrein as a New Class of Proteasome Inhibitors. Demasi, M, Felicio, AL, Pacheco AO, Leite HG, Lima, C, Andrade LH. Journal of the Brazilian Chemical Society, v. 21, p. 299-305, 2010.


  • Delayed local inflammatory response induced by Thalassophryne nattereri venom is related to extracellular matrix degradation. Pareja-Santos, A, Saraiva, TC, Costa, EP, Santos, MF, Zorn, TT, Souza, MV, Lopes-Ferreira, M, Lima, C. International Journal of Experimental Pathology, v. 90, p. 34-43, 2009. 
  • Characterization of a new bioactive peptide from Potamotrygon gr. orbignyi freshwater stingray venom. Conceição, K, Santos, JM, Bruni, FM, Klitzke, CF, Marques, EE, Borges, MH, Melo, RL, Fernandes, JH, Lopes-Ferreira, M. Peptides (New York, N.Y. 1980), v. 30, p. 2191-2199, 2009. 
  • Effect of mangiferin on the development of periodontal disease: involvement of lipoxin A4, anti-chemotaxic action in leukocyte rolling. Carvalho RR, Pellizzon, CH, Justolin JR, L, Felisbino, SL, Vilegas, W, Bruni, FM, Lopes-Ferreira, M, Hiruma-Lima, CA, Chemico-Biological Interactions, v. 179, p. 344-350, 2009. 
  • Simplified procedures for the isolation of HF3, bothropasin, disintegrin-like/cysteine-rich protein and a novel P-I metalloproteinase from Bothrops jararaca venom. Oliveira, AK, Paes Leme, A, Assakura, M, Menezes, MC, Zelanis, A, Tashima, AK, Lopes-Ferreira, M, Lima, C, Camargo, ACM, Fox, J, Serrano, SM. Toxicon, v. 53, p. 797-801, 2009. 
  • Anti-hemorrhagic activity of four brazilian vegetable species against Bothrops jararaca venom. Nishijima, CM, Rodrigues, CM, Silva, MA, Lopes-Ferreira, M, Vilegas, W, Hiruma-Lima, CA. Molecules (Basel), v. 14, p. 1072-1080, 2009. 
  • Antivenom action on renal effects induced by Thalassophryne nattereri venom. Martins, AM, Barbosa, PSF, Souza, DF, Alves, CD, Menezes, DB, Lima, C, Lopes-Ferreira, M, Fonteles, MC, Monteiro, HSA. Journal of Venomous Animals and Toxins Including Tropical Diseases (Online), v. 15, p. 125-135, 2009. 
  • Identification of bradykinin-related peptides from Phyllomedusa nordestina skin secretion using electrospray ionization tandem mass spectrometry after a single-step liquid chromatography. Conceição, K, Bruni, FM, Sciani, JM, Konno, K, Melo, RL, Antonizazzi, MM, Jared, C, Lopes-Ferreira, M, Pimenta, D.C. The Journal of Venomous Animals and Toxins Including Tropical Diseases (Online), v. 15, p. 633-652, 2009.
LETA - Laboratório Especial de Toxinologia Aplicada
Grupo de Pesquisa em Imunorregulação, Instituto Butantan
monica.lopesferreira@butantan.gov.br (11) 3726-1024